Background: This study aims to investigate the chlamydia pneumoniae infection (PC) in patients with coronary\nheart disease.\nMethods: A total of 92 patients with coronary heart disease, who were treated with percutaneous coronary\nintervention (PCI), were selected as the case group. In addition, 50 healthy people were enrolled as the control\ngroup. The incidences of CP infection and serum Chlamydia pneumoniae IgA antibody (CP-IgA), high sensitive Creactive\nprotein (hs-CRP), and interleukin-6 (IL-6) were compared in these two groups. The classification of coronary\nartery lesion, the incidence of perioperative cardiovascular events, and adverse prognosis events within six months\nafter procedure were compared.\nResults: The incidence of CP infection in the case group was higher (42.4% vs. 0%, P < 0.05). Furthermore, 17\npatients were at grade I, 39 patients were at grade II, and 36 patients were at grade III. The incidences for these\nthree kinds of patients were 17.6, 30.8, and 66.7%. The incidence of CP infection at grade III was higher than that of\ngrade I or II (P < 0.05). Serum CP-IgA, hs-CRP and IL-6 levels increased with the severity of the coronary artery\ndisease (P < 0.05), and the serum hs-CRP and IL-6 levels of patients with perioperative cardiovascular events were\nhigher (P < 0.05). Moreover, the serum CP-IgA levels of the patients with adverse prognosis events were also higher\n(P < 0.05).\nConclusions: Patients with coronary heart disease have a high CP infection rate. The degree of infection is relevant\nto the severity of the coronary artery lesions and postoperative prognosis of patients, suggesting that CP infection\nmay be an important factor affecting the incidence and prognosis of coronary heart disease.
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